Structure of the mammalian 80S initiation complex with initiation factor 5B on HCV-IRES RNA

By Hiroshi Yamamoto, A. Unbehaun, J. Loerke, E. Behrmann, M. Collier, J. Bürger, T. Mielke, C. Spahn. 2014

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Pervasive tertiary structure in the dengue virus RNA genome (2018, background): “Complex tertiary structure elements are widely used by viruses to mediate interactions with protein, RNA, and smallmolecule partners (8, 25, 27, 29, 30).”
Protein Synthesis Initiation in Eukaryotic Cells. (2018, background): “There is a large change in the conformation of 80S-bound eIF5B, where domains III and IV are rotated 60°–65° relative to free eIF5B (Fernandez et al. 2013; Yamamoto et al. 2014).”
Structures of ribosome-bound initiation factor 2 reveal the mechanism of subunit association (2016, background): “Whereas the eukaryotic initiation uses eukaryotic-specific subunit rolling (18, 29), the bacterial IF2-dependent initiation uses subunit rotation.”
Long-range interdomain communications in eIF5B regulate GTP hydrolysis and translation initiation (2020, background): “These operations involve tasks beyond large subunit recruitment, as it has been demonstrated that eIF5B exerts a critical role in initiation AUG codon selection accuracy or Met-tRNAi Met delivery in noncanonical scenarios like viral infection or cellular stress (29, 49).”
RACK1 on and off the ribosome (2019, methodology): “These positions are predicted to be within the dynamic range of FRET (about 70 and 90 Å away from the C-terminus of RACK1 for C44 and U56, respectively (Quade et al. 2015; Yamamoto et al. 2014); Fig.”