Thinking Outside the Triangle: Replication Fidelity of the Largest RNA Viruses.

By E. C. Smith, Nicole R. Sexton, M. Denison. 2014

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Elicitation of Potent Neutralizing Antibody Responses by Designed Protein Nanoparticle Vaccines for SARS-CoV-2 (2020, neutral): “…targeting several non-overlapping epitopes, which we expect to limit the potential for emergence and selection of escape mutants, especially since coronaviruses do not mutate quickly when compared to viruses such as influenza or human immunodeficiency virus (Li et al., 2020; Smith et al., 2014).”
Mechanisms of viral mutation (2016, background): “Supporting this correlation, however, coronaviruses have the largest genomes among RNA viruses (30–33 kb) and have evolved proofreading capacity, as opposed to all other RNA viruses known [11].”
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant (2020, unknown): “, 2018) and for encoding a 30-to-50-exoribonuclease that permits high-fidelity replication by the viral RNA-dependent RNA polymerase (Denison et al., 2011; Smith et al., 2014).”