Structural biology and chemistry of the terpenoid cyclases.

By D. Christianson. Chemical Reviews, 2006

705 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/54c1920de099a75c0be887d2927cf24cf9ae9bf6

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. M. Wink
2. J. Gershenzon
3. D. Tholl

In Molecular Biology

1. D. Tholl
2. M. Wink
3. J. Gershenzon
4. Tobias G. Köllner
5. J. Degenhardt

Citations in the corpus

• Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants. (2009, background): “Also, structural elucidation of complexes consisting of trichodiene synthase and an analog of the intermediate suggested the intermediates are present in thermodynamically preferred conformations rather than those expected from the course of the reaction mechanism (Christianson, 2006).”
• Biosynthesis and biological functions of terpenoids in plants. (2015, background): “A functionally active class I α-domain carries the highly conserved aspartate-rich motif, DDxxD, and a less conserved NSE/DTE motif, which are located on opposite sides of the entrance of the catalytic side and help position the diphosphate substrate by binding of a trinuclear magnesium cluster [215”
• Artificial Metalloenzymes: Reaction Scope and Optimization Strategies. (2018, background): “intermediates that react in a similar fashion with an intramolecular carbon nucleophile to create a C-C bond.(302) Researchers have demonstrated that Ru-catalyzed allylic substitution proceeds even inside of cells, making this reaction particularly attractive for in vivo applications.”
• Biochemistry of Terpenoids: Monoterpenes, Sesquiterpenes and Diterpenes (2010, background): “…been described (Guo et al., 1994; Dekraker et al., 1998; Lu et al., 2002; Dudareva et al., 2004), over 30 terpene synthase cDNAs have been isolated from plants (Table 5.2) and the first crystal structures of terpene synthases have been obtained (Starks et al., 1997; Christianson, 2006; Abe, 2007).”