Resolving the neural circuits of anxiety

By G. G. Calhoon, K. Tye. Nature Neuroscience, 2015

647 citations recorded by the source corpus.

Although anxiety disorders represent a major societal problem demanding new therapeutic targets, these efforts have languished in the absence of a mechanistic understanding of this subjective emotional state. While it is impossible to know with certainty the subjective experience of a rodent, rodent models hold promise in dissecting well-conserved limbic circuits. The application of modern approaches in neuroscience has already begun to unmask the neural circuit intricacies underlying anxiety by allowing direct examination of hypotheses drawn from existing psychological concepts. This information points toward an updated conceptual model for what neural circuit perturbations could give rise to pathological anxiety and thereby provides a roadmap for future therapeutic development.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Social Psychology

View Paper: https://www.semanticscholar.org/paper/53f9b4f272f4d9ec26fc1a7752f3d152df8797cc

Citations in the corpus

• Cortical-limbic circuit dynamics of approach-avoidance conflict in humans (2026, unknown): “Using a variety of approaches, researchers have identi fi ed pairs of prefrontal-limbic regions, mediated by theta-band power, associated with avoidance behavior on these tasks 22 – 24 .”