The Role of Default Network Deactivation in Cognition and Disease

By Alan Anticevic, Michael W. Cole, John D. Murray, Philip R. Corlett, John H. Krystal. Trends in Cognitive Sciences, 2012

937 citations recorded by the source corpus.

A considerable body of evidence has accumulated over recent years on the functions of the default-mode network (DMN) – a set of brain regions whose activity is high when the mind is not engaged in specific behavioral tasks and low during focused attention on the external environment. In this review, we focus on DMN suppression and its functional role in health and disease, summarizing evidence that spans several disciplines, including cognitive neuroscience, pharmacological neuroimaging, clinical neuroscience, and theoretical neuroscience. Collectively, this research highlights the functional relevance of DMN suppression for goal-directed cognition, possibly by reducing goal-irrelevant functions supported by the DMN (e.g., mind- wandering), and illustrates the functional significance of DMN suppression deficits in severe mental illness.

Subfields: Cognitive Neuroscience, Experimental and Cognitive Psychology

View Paper: https://www.semanticscholar.org/paper/53ec2fceb5c458e62f74ac68477b5270f4825a82

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Citations in the corpus

High intelligence: A risk factor for psychological and physiological overexcitabilities (2018, background): “Those who have mood disorders seem to have connections and networks that stay excitable instead of shutting down, rendering their nervous system unable to fully relax (Anticevic et al., 2012).”
Creative Cognition and Brain Network Dynamics (2015, background): “During working memory tasks, for example, the control network typically shows increased activation while the default network deactivates, presumably reflecting the suppression of task-unrelated thoughts during cognitive control [16].”
Robust prediction of individual creative ability from brain functional connectivity (2018, background): “Notably, neuroimaging studies of artistic performance have also reported functional coupling among regions within these networks (12, 24, 25), suggesting that the ability to coactivate brain systems that tend to work in opposition at rest and during demanding cognitive tasks (14) may reflect a domai”
Depressive Rumination, the Default-Mode Network, and the Dark Matter of Clinical Neuroscience (2015, background): “The perspective afforded by emerging knowledge of the IFC of the brain has provided clinical neuroscientists with a means of conceptualizing the neural substrates of psychopathology (9–11).”
Default Mode Network Mechanisms of Transcranial Magnetic Stimulation in Depression (2014, background): “Interactions between the DMN and CEN are thought to be critical for regulating internally oriented versus externally oriented processing and optimizing cognition (18,19,72,73).”
Intrinsic and task-evoked network architectures of the human brain. (2014, neutral): “The consistent FC decrease between fronto-parietal and default-mode systems is also notable, given evidence that the fronto-parietal system contributes to decreases in default-mode activity during a variety of tasks (Anticevic et al., 2012; Raichle, 2010).”