Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging

By Linda S. Steelman, W. Chappell, Stephen L. Abrams, Ruth C. Kempf, Jacquelyn M. Long, P. Laidler, S. Mijatović, D. Maksimović‐Ivanić, F. Stivala, M. C. Mazzarino and 15 more. Aging, 2011

669 citations recorded by the source corpus.

Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation and decreased sensitivity to apoptotic-inducing agents are typically associated with activation of these pro-survival pathways. This review discusses the functions these pathways have in normal and neoplastic tissue growth and how they contribute to resistance to apoptotic stimuli. Crosstalk and commonly identified mutations that occur within these pathways that contribute to abnormal activation and cancer growth will also be addressed. Finally the recently described roles of these pathways in cancer stem cells, cellular senescence and aging will be evaluated. Controlling the expression of these pathways could ameliorate human health.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/53826a084791cf70302a84a4d219f0307f264889

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. M. Sekhoacha
  2. Keamogetswe Riet
  3. Lemohang Gumenku
  4. Paballo Motloung
  5. A. Adegoke
  6. S. Mashele

Citations in the corpus