Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

By R. Hotchkiss, Guillaume Monneret, D. Payen. Nature reviews. Immunology, 2013

2,432 citations recorded by the source corpus.

Sepsis — which is a severe life-threatening infection with organ dysfunction — initiates a complex interplay of host pro-inflammatory and anti-inflammatory processes. Sepsis can be considered a race to the death between the pathogens and the host immune system, and it is the proper balance between the often competing pro- and anti-inflammatory pathways that determines the fate of the individual. Although the field of sepsis research has witnessed the failure of many highly touted clinical trials, a better understanding of the pathophysiological basis of the disorder and the mechanisms responsible for the associated pro- and anti-inflammatory responses provides a novel approach for treating this highly lethal condition. Biomarker-guided immunotherapy that is administered to patients at the proper immune phase of sepsis is potentially a major advance in the treatment of sepsis and in the field of infectious disease.

Subfields: Epidemiology, Immunology, Nutrition and Dietetics

View Paper: https://www.semanticscholar.org/paper/535b719c0a9114acd54c6d38be1a88c7941aa466

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In Epidemiology

1. Derek C. Angus
2. Min Huang
3. S. Maggini
4. H. Prescott
5. A. Carr
6. Jingqian Su
7. Shaoli Cai

In Immunology

1. Derek C. Angus
2. Min Huang
3. S. Maggini
4. H. Prescott
5. A. Carr
6. Jingqian Su
7. Shaoli Cai

In Nutrition and Dietetics

1. S. Maggini
2. Derek C. Angus
3. Min Huang
4. H. Prescott
5. Jingqian Su
6. Shaoli Cai

Citations in the corpus

• Enhancing Recovery From Sepsis (2018, positive): “Many patients continue to have inflammatory changes, immune suppression, or both after sepsis.(19)”
• Vitamin C and Immune Function (2017, background): “Supplementation of healthy human volunteers with 1 g/day vitamin C (with and without vitamin E) was shown to enhance peripheral blood mononuclear cell-derived IL-10, IL-1, and TNF-α following stimulation with LPS [87,94].”
• Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update (2019, background): “Subsequently, this initial hyperinflammatory phase evolves over several days into a more protracted immunosuppressive phase [98].”
• The Pathogenesis of Sepsis and Potential Therapeutic Targets (2019, methodology): “In a mouse model of sepsis developed using cecal ligation and puncture (CLP), incomplete autophagy might lead to cardiac dysfunction in sepsis, and autophagy activation by rapamycin restores cardiac function and reduces CLP-induced myocardial damage [19].”