The importance of experimental design and QC samples in large-scale and MS-driven untargeted metabolomic studies of humans.

420 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Metabolomics for Investigating Physiological and Pathophysiological Processes. (2019, methodology): “Regardless of whether one uses targeted or untargeted metabolomics, both methods require the use of internal standards and quality control (QC) samples (55, 128, 508).”
metaX: a flexible and comprehensive software for processing metabolomics data (2017, background): “These effects can detrimentally impact the significant signal discovery and MS features that are required for rigorous quality assurance [14, 18].”