FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like Properties

By Steffen Frey, R. Richter, D. Görlich. Science, 2006

657 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5335859d3042422b789edd10bc34fefdfbc42312

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In Molecular Biology

Citations in the corpus

Phase Transition of a Disordered Nuage Protein Generates Environmentally Responsive Membraneless Organelles (2015, background): “In the cases of assembly of EWS/FUS proteins, P bodies, and the nuclear pore complex, formation is facilitated by repeated occurrences of the dipeptides YG/RG, QN, and FG, respectively (Balagopal and Parker, 2009; Decker et al., 2007; Frey et al., 2006; Kato et al., 2012; Sun et al., 2011).”
Cell-Free Formation of RNA Granules: Low Complexity Sequence Domains Form Dynamic Fibers Within Hydrogels (2012, background): “Hydrogels not unlike what we describe in this report have been observed upon expression, purification, and concentration of the Nsp1p component of nuclear pores (Frey andGörlich, 2007; Frey et al., 2006).”
The nuclear pore complex and nuclear transport. (2010, neutral): “A different view is provided by the “saturated” model (Frey et al. 2006; Frey and Gorlich 2007), originally the “hydrophobic gel” model (Ribbeck and Gorlich 2002).”
Pi-Pi contacts are an overlooked protein feature relevant to phase separation (2018, background): “…intracellular domain (NICD) (Pak et al., 2016), polyglutamine tracts (Crick et al., 2013), tropoelastin (Yeo et al., 2011), FUS (Burke et al., 2015; Kato et al., 2012), Ddx4 and the homologous LAF-1 (Nott et al., 2015; Elbaum-Garfinkle et al., 2015) and FG-repeat nucleoporins (Frey et al., 2006).”
Competing protein-RNA interaction networks control multiphase intracellular organization (2020, neutral): “In principle, compositional specificity might be encoded by unique RBD-RNA interactions combined with stable self-oligomerization or additive weakly interacting IDR stickers (‘‘self-associating IDRs’’), both of which are sufficient for LLPS in vitro (Feric et al., 2016; Frey et al., 2006; Kato et al”
Phase separation in biology; functional organization of a higher order (2016, background): “These studies highlight the roles of cation-π [48] and π-π [50, 51] interactions in phase separation phenomena.”
Molecular mechanism of the nuclear protein import cycle (2007, background): “Alternatively, it has been proposed that the FG-nucleoporin repeats form a sieve-like gel through interactions between hydrophobic FG core”
Comprehending crystalline β-carotene accumulation by comparing engineered cell models and the natural carotenoid-rich system of citrus (2011, neutral): “Because of the flexibility of FG repeat domains, it was proposed that phenylalanine-mediated inter-repeat interactions cross-linked the FG repeat domains into elastic and reversible hydrogels (Frey et al., 2006).”