The Genomic Landscapes of Human Breast and Colorectal Cancers

By L. Wood, D. W. Parsons, Siân Jones, Jimmy Lin, T. Sjöblom, R. Leary, D. Shen, S. Boca, T. Barber, Janine Ptak and 32 more. Science, 2007

2,499 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/5328db55d93a77fcdd6638e23f21226f1108cdb8

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In Cancer Research

In Molecular Biology

In Pathology and Forensic Medicine

Citations in the corpus

Cancer systems biology: a network modeling perspective (2009, background): “INTRODUCTION The advent of genomic sequencing and copy-number evaluation has revealed that aspirations for understanding cancer in terms of mutation of some limited number of oncogenes and tumor suppressor genes are unlikely to be fulfilled; instead, even tumors of a particular tissue type bear high”
Modeling Oncogenic Signaling in Colon Tumors by Multidirectional Analyses of Microarray Data Directed for Maximization of Analytical Reliability (2010, background): “Recently, no more than a dozen or so somatic ‘‘driver’’ mutations were established as being responsible for CRC development [3,4].”
Overexpressed of RAD51 suppresses recombination defects: a possible mechanism to reverse genomic instability (2010, background): “Interestingly, there is also evidence that point mutations in known HRR genes are not common in either breast or colorectal cancers (31).”
A molecularly annotated platform of patient-derived xenografts ("xenopatients") identifies HER2 as an effective therapeutic target in cetuximab-resistant colorectal cancer. (2011, background): “Mouse-passaged colorectal cancer samples have already been used for genome-wide mutational studies and for copy number variation surveys (21, 22).”
Clonal competition with alternating dominance in multiple myeloma. (2012, neutral): “MC0518 1 del not tested (24) 2 del (36)”
Algorithms for Detecting Significantly Mutated Pathways in Cancer (2010, neutral): “some recent works resequenced hundreds of genes [31, 8] while others examine nearly all known protein-coding genes in the human genome [40, 18, 32].”
Integrating personalized gene expression profiles into predictive disease-associated gene pools (2017, background): “For example, breast and colorectal tumors typically contain about 80 mutated genes.(16) Yet, the mutations in different tumors have very little overlap, so that in only 22 tumors an astonishing total of more than 1700 mutated genes has been identified.”
Comprehensive Molecular Characterization of Human Colon and Rectal Cancer (2012, background): “Lander(4,6,7), Stacey Gabriel(8), Gad Getz(4), Washington University in St.”
A human functional protein interaction network and its application to cancer data analysis (2010, methodology): “Recently, several large-scale genome-wide screening projects have revealed common core signaling pathways in the etiology or progression of several cancer types [10-14], indicating the relevance of pathway-based analysis for the understanding of large scale disease data sets.”