New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
By Eva L. Feldman, D. Bennett, K. Nave, T. S. Jensen. Neuron, 2017
816 citations recorded by the source corpus.
Pre-diabetes and diabetes are a global epidemic, and the associated neuropathic complications create a substantial burden on both the afflicted patients and society as a whole. Given the enormity of the problem and the lack of effective therapies, there is a pressing need to understand the mechanisms underlying diabetic neuropathy (DN). In this review, we present the structural components of the peripheral nervous system that underlie its susceptibility to metabolic insults and then discuss the pathways that contribute to peripheral nerve injury in DN. We also discuss systems biology insights gleaned from the recent advances in biotechnology and bioinformatics, emerging ideas centered on the axon-Schwann cell relationship and associated bioenergetic crosstalk, and the rapid expansion in our knowledge of the mechanisms contributing to neuropathic pain in diabetes. These recent advances in our understanding of DN pathogenesis are paving the way for critical mechanism-based therapy development.
Subfields: Cellular and Molecular Neuroscience, Neurology, Physiology
View Paper: https://www.semanticscholar.org/paper/53269b7b2dd0703e21b54fdf474cc48c10a6dd75
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
- Yue Liu
- G. Ros
- Keji Chen
- Mengqi Gao
- Luqi Huang
- P. Lozano
- Wenting Wang
- Yanfei Liu
Citations in the corpus
- Diabetic vascular diseases: molecular mechanisms and therapeutic strategies (2023, background): “Neurons and Schwann cells are highly susceptible to hyperglycemia.(273,274) Energy and inflammation, oxidative stress,(275) insulin resistance,(276) AGEs,(277) nerve growth factors,(278) activation of the polyol pathway,(279) and activation of the hexosamine and PKC pathways(280) are core pathologic”
- Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections (2023, background): “They are called aberrant or collateral glucose metabolism [58].”