The role of metabolism in the pathogenesis of osteoarthritis

By A. Mobasheri, M. Rayman, O. Gualillo, J. Sellam, P. M. Kraan, U. Fearon. Nature Reviews Rheumatology, 2017

672 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments (2022, background): “This leads to cartilage degeneration and chondrocyte senescence.(351,352) The expression of glycolysis-related genes, such as Glut-1, hexokinase II and PKM2, is increased in the chondrocytes of OA patients.”
The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis. (2020, background): “Alterations in metabolic homeostasis and metabolic reprogramming also occur in synovial fibroblasts and immune cells of the joint, including synovial macrophages in OA (Karonitsch et al., 2018; Mahon et al., 2019; Mobasheri et al., 2017).”
Osteoarthritis: pathogenic signaling pathways and therapeutic targets (2023, background): “In the past decades, more and more evidence suggests that metabolism plays a crucial role in maintaining the energy homeostasis of articular chondrocytes and that abnormalities in chondrocyte metabolism can lead to the onset and progression of OA.(132,133) Abnormally accelerated catabolism of articu”