G Protein-Coupled Receptors as Targets for Approved Drugs: How Many Targets and How Many Drugs?
By K. Sriram, P. Insel. 2018
1,044 citations recorded by the source corpus.
Subfields: Computational Theory and Mathematics, Molecular Biology, Pharmacology
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In Computational Theory and Mathematics
In Molecular Biology
Citations in the corpus
- How accurately can one predict drug binding modes using AlphaFold models? (2023, background): “First, GPCRs represent the largest class of drug targets by a substantial margin, with 35% of FDA-approved drugs targeting a GPCR ( Sriram and Insel, 2018 ).”
- Exploring the free-energy landscape of GPCR activation (2018, background): “Therefore, GPCRs are important in understanding molecular determinants of human diseases, emphasized by considering that 40–50% of pharmaceutical drugs target them (2, 3), and more novel therapeutics await discovery as our knowledge of these versatile receptors grows.”