The cell biology of osteoclast function.

By H. Väänänen, Haibo Zhao, M. Mulari, J. Halleen. Journal of Cell Science, 2000

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Normal bone anatomy and physiology. (2008, background): “The sealing zone surrounds and isolates the acidified resorption compartment from the surrounding bone surface (32).”
Dual effect of strontium ranelate: stimulation of osteoblast differentiation and inhibition of osteoclast formation and resorption in vitro. (2008, background): “On the other hand, when cultured on apatite mineral (corresponding to the mineral phase of bone), they are basoapically polarized and exhibit at the osteoclast/mineralized substratum interface an actin-rich structure, the sealing zone, which seals off the resorption area [33,41].”
Loss of the ClC-7 chloride channel leads to osteopetrosis in mice and man. (2001, unknown): “Finally, mutations of ClC-5 cause Dent’s disease (Lloyd et al., 1996), a disorder characterized by proteinuria and kidney stones.”
Silk fibroin as biomaterial for bone tissue engineering. (2016, background): “Osteoclasts are multinucleated cells derived from hematopoietic stem cells [16], which dissolve crystalline HA through release of hydrochloric acid and a mixture of proteases which degrades the organic bone matrix rich in collagen fibers [17].”