Advances in Microfluidic PCR for Point-of-Care Infectious Disease Diagnostics

By Seungkyung Park, Yi Zhang, Shin Lin, Tza-Huei Wang, Samuel Yang. Biotechnology Advances, 2011

307 citations recorded by the source corpus.

Global burdens from existing or emerging infectious diseases emphasize the need for point-of-care (POC) diagnostics to enhance timely recognition and intervention. Molecular approaches based on PCR methods have made significant inroads by improving detection time and accuracy but are still largely hampered by resource-intensive processing in centralized laboratories, thereby precluding their routine bedside- or field-use. Microfluidic technologies have enabled miniaturization of PCR processes onto a chip device with potential benefits including speed, cost, portability, throughput, and automation. In this review, we provide an overview of recent advances in microfluidic PCR technologies and discuss practical issues and perspectives related to implementing them into infectious disease diagnostics.

Subfields: Biomedical Engineering

View Paper: https://www.semanticscholar.org/paper/52e943b7ff4796b3291b140a6a16eb471e25e5ac

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In Biomedical Engineering

1. Safa A. Damiati
2. U. Kompella
3. Rimantas Kodzius
4. Samar Damiati

Citations in the corpus

• Microfluidic Devices for Drug Delivery Systems and Drug Screening (2018, methodology): “The droplet generation strategies include: (i) hydrodynamics (T- and Y-junction, flow-focusing, and co-flowing); (ii) pneumatic pressure, which uses gas pressure as a shear force and a driving force to form droplets; (iii) optical techniques that use optical force to form the particles; and (iv) ele”