Hepatocellular carcinoma in cirrhosis: incidence and risk factors.

By G. Fattovich, T. Stroffolini, I. Zagni, F. Donato. Gastroenterology, 2004

2,553 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/52e27b8f9b16d98bb1ea8d52ed36c0ba40f5f767

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Citations in the corpus

The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide. (2006, background): “Compared with other causes of cirrhosis, chronic infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) is associated with a higher risk of developing HCC [3,5].”
Promotion of Hepatocellular Carcinoma by the Intestinal Microbiota and TLR4 (2012, background): “Notably, 80% of HCCs develop in fibrotic or cirrhotic livers as a consequence of chronic liver injury (Fattovich et al., 2004; Luedde and Schwabe, 2011) with HCC being the leading cause of death in patients with compensated liver cirrhosis (Fattovich et al., 2004).”
Epidemiology of Hepatocellular Carcinoma in the United States: Where Are We? Where Do We Go? (2014, background): “The highest 5-year cumulative risks are observed in HCV cirrhosis (17% in the West and 30% in Japan), hemochromatosis (21%), HBV cirrhosis (10% in the West and 15% in Asia), alcoholic cirrhosis (8%-12%), and biliary cirrhosis (4%).(10,11)”
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. (2012, background): “5%/year or greater would warrant surveillance of HCC in cirrhotic patients [49], irrespective of its etiology [10,17,50,51].”
AASLD guidelines for the treatment of hepatocellular carcinoma (2018, background): “HCC meets the criteria for the development of a surveillance program((11)) given that patients with cirrhosis are a high-risk group((7)) and can be readily identified.”
Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma (2007, positive): “Nodular lesions were categorized as follows: (1) conclusive HCC diagnosis: nodules displaying intense contrast enhancement in the arterial phase and washout in 1 of the venous phases (portal or delayed), (2) suggestive of HCC, but nonconclusive: nodules showing enhancement during the hepatic arteria”
Diagnosis, Staging, and Management of Hepatocellular Carcinoma: 2018 Practice Guidance by the American Association for the Study of Liver Diseases (2018, background): “However, most studies does show that the risk of HCC increases markedly in those with cirrhosis.(28) HCC incidence among patients without cirrhosis ranged from 0.”
Alpha-fetoprotein, Des-gamma Carboxyprothrombin, and Lectin-Bound Alpha-fetoprotein in Early Hepatocellular Carcinoma (2009, background): “Cirrhosis is the most important risk factor in the development of HCC and represents an opportunity for surveillance (7).”
EASL clinical practice guidelines: Management of chronic hepatitis B virus infection. (2012, background): “The annual incidence of HBV-related HCC in patients with CHB is high, ranging from 2% to 5% when cirrhosis is established [13].”
Update on Prevention, Diagnosis, and Treatment and of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance (2018, background): “Other subgroups with a higher risk of HCC include persons with HCV, HDV, or HIV coinfections and those with fatty liver.((55,136-139)) At this time, there is insufficient evidence to recommend HCC surveillance in children except in children with cirrhosis or with a first-degree family member with HC”
Matrix Stiffness Modulates Proliferation, Chemotherapeutic Response and Dormancy in Hepatocellular Carcinoma Cells (2011, background): “The majority (80%) of HCCs develop in the context of advanced liver fibrosis or cirrhosis and liver cirrhosis is the single most important risk factor for HCC development (2).”