Cytokine‐Induced Sickness Behavior: Mechanisms and Implications

By Robert Dantzer. Annals of the New York Academy of Sciences, 2001

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An fMRI Study of Cytokine-Induced Depressed Mood and Social Pain: The Role of Sex Differences (2009, background): “Sickness behavior includes symptoms such as fatigue, anhedonia, reduced social activity, and increased pain sensitivity (Dantzer, 2001; Hart, 1988; Kent et al., 1992).”
Cytokines and major depression. (2005, background): “Sickness behaviour is typically accompanied by fever and a variety of behavioural responses, including decreased appetite, anorexia, weight loss, fatigue, sleep disturbances, retardation of motor activity, reduced interest in the physical and social environment, loss of libido, impaired cognitive ab”
Curcumin and cancer: an "old-age" disease with an "age-old" solution. (2008, background): “Animal models of ‘‘sickness behavior” support this thesis [236,237], in that fluctuations in inflammatory cytokines, primarily IL-1, IL-6, and TNF-a, are related to fluctuations in components of sickness in animals (e.”