DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways

By Ioannis S. Vlachos, Nikos Kostoulas, Thanasis Vergoulis, G. Georgakilas, Martin Reczko, Manolis Maragkakis, Maria D. Paraskevopoulou, Kostantinos Prionidis, Theodore Dalamagas, Artemis G. Hatzigeorgiou. Nucleic Acids Res., 2012

540 citations recorded by the source corpus.

MicroRNAs (miRNAs) are key regulators of diverse biological processes and their functional analysis has been deemed central in many research pipelines. The new version of DIANA-miRPath web server was redesigned from the ground-up. The user of DNA Intelligent Analysis (DIANA) DIANA-miRPath v2.0 can now utilize miRNA targets predicted with high accuracy based on DIANA-microT-CDS and/or experimentally verified targets from TarBase v6; combine results with merging and meta-analysis algorithms; perform hierarchical clustering of miRNAs and pathways based on their interaction levels; as well as elaborate sophisticated visualizations, such as dendrograms or miRNA versus pathway heat maps, from an intuitive and easy to use web interface. New modules enable DIANA-miRPath server to provide information regarding pathogenic single nucleotide polymorphisms (SNPs) in miRNA target sites (SNPs module) or to annotate all the predicted and experimentally validated miRNA targets in a selected molecular pathway (Reverse Search module). DIANA-miRPath v2.0 is an efficient and yet easy to use tool that can be incorporated successfully into miRNA-related analysis pipelines. It provides for the first time a series of highly specific tools for miRNA-targeted pathway analysis via a web interface and can be accessed at http://www.microrna.gr/miRPathv2.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5269f8e158a68a94bf582dcfb99ce7caa9c4e446

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

In Molecular Biology

Citations in the corpus

The multiMiR R package and database: integration of microRNA–target interactions along with their disease and drug associations (2014, methodology): “For a more focused analysis on the overall effects of miRNA on regulation of pathways, there are several tools to study pathways affected by miRNA (21,25,46).”
DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions (2014, unknown): “0 (28), microT-CDS (29) and LncBase (30), respectively.”
DIANA-microT web server v5.0: service integration into miRNA functional analysis workflows (2013, methodology): “By using meta-analysis statistics, the server combines the P-values from each repetition into a total P-value for each miRNA, signifying its effect on the selected genes for all used thresholds (15,16).”