Aligned collagen is a prognostic signature for survival in human breast carcinoma.

By M. Conklin, J. Eickhoff, K. Riching, Carolyn Pehlke, Kevin W. Eliceiri, Paolo P. Provenzano, A. Friedl, P. Keely. American Journal of Pathology, 2011

1,208 citations recorded by the source corpus.

Subfields: Cancer Research, Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/5206fe92b4d7709485c6291bf0f05d25560dbb08

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Lance L. Munn
2. Rakesh K. Jain
3. M. Swartz
4. Zena Werb
5. Andrew J. Ewald
6. Hadi Tavakoli Nia
7. H. Wiig
8. E. Cukierman

In Oncology

1. Rakesh K. Jain
2. H. Wiig
3. Lance L. Munn
4. Andrew J. Ewald
5. M. Swartz
6. Zena Werb
7. E. Cukierman
8. Pengfei Lu

In Pathology and Forensic Medicine

1. Rakesh K. Jain
2. H. Wiig
3. M. Swartz

Citations in the corpus

• Biomechanical remodeling of the microenvironment by stromal Caveolin-1 favors tumor invasion and metastasis (2011, background): “Recent reports propose quantification of collagen alignment at the tumor boundary as a predictor of breast cancer survival (Conklin et al., 2011).”
• Physical traits of cancer (2020, background): “Studies of 3D matrix architecture, mainly focused on collagen, show that collagen organization can be a prognostic biomarker (119) and that certain arrangements facilitate cancer cell migration, proliferation, and actomyosin contractility (120, 121).”
• Computational segmentation of collagen fibers from second-harmonic generation images of breast cancer (2014, methodology): “Furthermore, an algorithm that identifies collagen fiber characteristics in tissue samples may enable large-scale studies of tumor-associated collagen signatures supporting the manual analysis performed previously.(7) To our knowledge, FIRE has not been applied to SHG images of collagen in tissue.”
• Interstitial fluid and lymph formation and transport: physiological regulation and roles in inflammation and cancer. (2012, background): “For example, increased mammary tissue density correlates with poor prognosis of patients with breast cancer, and collagen alignment in the stroma of breast tumors negatively correlates with survival (92).”
• Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program (2013, methodology): “To study collective invasion, we cultured tumor organoids in 3D collagen I gels, a model for the microenvironment surrounding invasive breast cancers (Conklin et al., 2011; Nguyen-Ngoc et al., 2012; Paszek et al., 2005; Provenzano et al., 2008; Wolf et al., 2009).”