The myriad roles of cyclic AMP in microbial pathogens, from signal to sword
By K. McDonough, Ana Rodríguez. 2011
314 citations recorded by the source corpus.
All organisms must sense and respond to their external environments, and this signal transduction often involves second messengers such as cyclic nucleotides. One such nucleotide is cyclic AMP, a universal second messenger that is used by diverse forms of life, including mammals, fungi, protozoa and bacteria. In this review, we discuss the many roles of cAMP in bacterial, fungal and protozoan pathogens and its contributions to microbial pathogenesis. These roles include the coordination of intracellular processes, such as virulence gene expression, with extracellular signals from the environment, and the manipulation of host immunity by increasing cAMP levels in host cells during infection.
Subfields: Epidemiology, Infectious Diseases, Oncology
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Citations in the corpus
- Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein (2023, background): “In the last 2 decades, cNMP signaling networks have been characterized in several bacterial species and different CRPs have been studied for their cNMP and DNA binding properties (3, 6, 10, 76).”
- Cyclic AMP Signaling in Mycobacteria (2014, background): “tuberculosis is the first shown to secrete premade cAMP (9, 44).”
- Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. (2016, background): “In other bacterial species, cAMP signalling was found to be mostly related to virulence and quorum sensing (reviewed in McDonough & Rodriguez, 2011).”
- Microbial Surface Colonization and Biofilm Development in Marine Environments (2015, background): “Second messenger molecules are employed in many microbial environmental signaling pathways to relay external signals from membrane receptors to intracellular effectors (476).”
- Plant-activated bacterial receptor adenylate cyclases modulate epidermal infection in the Sinorhizobium meliloti–Medicago symbiosis (2012, background): “Second, it suppresses host immune responses by manipulating host cAMP-signaling pathways, either by injection of AC toxins and/or effector molecules or by direct secretion of cAMP into macrophages (26).”