The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease.
By Kassem Makki, E. Deehan, J. Walter, F. Bäckhed. Cell Host and Microbe, 2018
2,081 citations recorded by the source corpus.
Food is a primordial need for our survival and well-being. However, diet is not only essential to maintain human growth, reproduction, and health, but it also modulates and supports the symbiotic microbial communities that colonize the digestive tract-the gut microbiota. Type, quality, and origin of our food shape our gut microbes and affect their composition and function, impacting host-microbe interactions. In this review, we will focus on dietary fibers, which interact directly with gut microbes and lead to the production of key metabolites such as short-chain fatty acids, and discuss how dietary fiber impacts gut microbial ecology, host physiology, and health. Hippocrates' notion "Let food be thy medicine and medicine be thy food" remains highly relevant millennia later, but requires consideration of how diet can be used for modulation of gut microbial ecology to promote health.
Subfields: General Health Professions, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/51fb1e372be71d2db7e78059921dbed50d69bc88
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Citations in the corpus
- Gut Microbiota and Short Chain Fatty Acids: Implications in Glucose Homeostasis (2022, background): “This interaction influences the development and maturation of several cells within lymphoid tissues of the intestinal immune system [10,11].”
- Gut microbiota-derived metabolites as central regulators in metabolic disorders (2020, background): “63 In rodents with diabetes and obesity, supplementation with SCFAs improves the metabolic phenotype by increasing energy expenditure, glucose tolerance and homeostasis.”