Human Ageing Genomic Resources: Integrated databases and tools for the biology and genetics of ageing
By Robi Tacutu, Thomas Craig, A. Budovsky, D. Wuttke, Gilad Lehmann, Dmitri Taranukha, Joana Cósta, V. Fraifeld, J. P. D. Magalhães. Nucleic Acids Res., 2012
554 citations recorded by the source corpus.
The Human Ageing Genomic Resources (HAGR, http://genomics.senescence.info) is a freely available online collection of research databases and tools for the biology and genetics of ageing. HAGR features now several databases with high-quality manually curated data: (i) GenAge, a database of genes associated with ageing in humans and model organisms; (ii) AnAge, an extensive collection of longevity records and complementary traits for >4000 vertebrate species; and (iii) GenDR, a newly incorporated database, containing both gene mutations that interfere with dietary restriction-mediated lifespan extension and consistent gene expression changes induced by dietary restriction. Since its creation about 10 years ago, major efforts have been undertaken to maintain the quality of data in HAGR, while further continuing to develop, improve and extend it. This article briefly describes the content of HAGR and details the major updates since its previous publications, in terms of both structure and content. The completely redesigned interface, more intuitive and more integrative of HAGR resources, is also presented. Altogether, we hope that through its improvements, the current version of HAGR will continue to provide users with the most comprehensive and accessible resources available today in the field of biogerontology.
Subfields: Aging, Genetics, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/51ba5018727e674821fb57da0cef9c8598e47690
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Citations in the corpus
- Generation length for mammals (2013, methodology): “Sources_AdultBodyMass: AnAge, Animal Diversity, Encyclopedia of Life (eol. org/), Nowak and Paradiso 1999, PanTHERIA, Smith et al. 2003, Verde Arregoitia et al. 2013, Mean congenerics, Mean_confamilials; 8.”
- Human Ageing Genomic Resources: new and updated databases (2017, methodology): “Herein, the use and function of GenDR will be briefly outlined along with updates since the 2013 HAGR paper (3).”
- A global analysis of traits predicting species sensitivity to habitat fragmentation (2017, methodology): “Additional demographic data for all species were obtained from the Animal Aging and Longevity database (Tacutu et al., 2013).”