Replacement

By R. Pressat. 1980

30 31 Objective: Microangiopathy and dysregulation of the immune system play important roles in the 32 pathogenesis of Systemic Sclerosis (SSc). Factors that trigger vascular injury in SSc have not been 33 elucidated so far. To evaluate whether sex or expression of specific antinuclear auto-antibodies might 34 associate with the degree of microangiopathy we performed a systematic review summarizing what is 35 known about these associations. 36 Method: Standardized search of PubMed, EMBASE, Web of Science and the Cochrane library were 37 performed to identify studies, that report on auto-antibodies in SSc patients and microangiopathy, and for 38 the second search, that report on sex and microangiopathy. 39 Result: Eleven studies were included that report on the relationship between SSc specific auto-antibodies 40 and microangiopathy, and six studies were included that report on the association between sex and 41 microangiopathy. Contradictory results were found on the association between auto-antibodies and 42 microangiopathy, and no association was found between sex and microangiopathy based on the current 43 literature. 44 Conclusion: Based on this review of the literature we can conclude that sex does not seem to influence 45 degree of microangiopathy in SSc, while results on association between SSc specific auto-antibodies and 46 degree of microangiopathy were inconclusive. 47 modalities: NVC, dermoscopy, confocal microscopy, image

Citations in the corpus

I-TASSER-MR: automated molecular replacement for distant-homology proteins using iterative fragment assembly and progressive sequence truncation (2017, neutral): “MrBUMP used FASTA and/or SSM to pick up templates and then used multiple methods to prepare search models for MR (5,6).”
BALBES: a molecular-replacement pipeline (2007, neutral): “Nevertheless, several automated molecular-replacement pipelines have already been made available to the user community, including NORMA (Delarue, 2008), MrBUMP (Keegan & Winn, 2008) and part of the JSCS structure-solution pipeline (Schwarzen-bacher et al. , 2008).”
AMPLE: a cluster-and-truncate approach to solve the crystal structures of small proteins using rapidly computed ab initio models. (2012, unknown): “All ensembles generated were fed into MrBUMP (Keegan & Winn, 2008) using its default protocol (a version of MrBUMP later than or including that distributed in CCP 4 v.6.3.0 is required) and MR was carried out by both Phaser (Storoni et al. , 2004; McCoy et al. , 2005, 2007) and MOLREP (Vagin &…”
Using iterative fragment assembly and progressive sequence truncation to facilitate phasing and crystal structure determination of distantly related proteins. (2016, unknown): “In addition, automated pipelines such as CaspR (Claude et al. , 2004), MrBUMP (Keegan & Winn, 2008) and BALBES (Long et al. , 2008) were created to use multiple homologous template search models in order to enhance the success rate of MR.”
Phaser.MRage: automated molecular replacement (2013, unknown): “Quality scores in both BALBES and MrBUMP are derived from reﬁnement.”
Improved Technologies Now Routinely Provide Protein NMR Structures Useful for Molecular Replacement (2011, unknown): “, 2003), MrBUMP (Keegan and Winn, 2008), Beast (Read, 2001), Phaser (McCoy et al.”