High-plex imaging of RNA and proteins at subcellular resolution in fixed tissue by spatial molecular imaging.

By Shanshan He, R. Bhatt, Carl Brown, Emily A Brown, Derek L. Buhr, Kan Chantranuvatana, P. Danaher, D. Dunaway, Ryan G. Garrison, G. Geiss and 28 more. Nature Biotechnology, 2022

648 citations recorded by the source corpus.

Subfields: Biophysics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/50d126d2faa16363088dd1ee9fd55b15fe3fb3c8

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In Biophysics

1. Ling Shao
2. Huan Fu

In Molecular Biology

1. Huan Fu
2. Kok Siong Ang
3. Jinmiao Chen

Citations in the corpus

• Unsupervised spatially embedded deep representation of spatial transcriptomics (2021, methodology): “Commercial vendors like 10 × Genomics, Vizgen, and Nanostring are debut-ing their imaging-based methods, Xenium [23], MER-SCOPE, and CosMX [24], respectively, which also offer sub-cellular resolution.”
• Methods and applications for single-cell and spatial multi-omics (2023, methodology): “…automated imaging-based spatial transcriptome profiling of tissue sections at single-cell resolution, including the NanoString CosMx (smFISH-based) 126 , Vizgen MER-SCOPE (MERFISH-based) 127 and 10x Genomics Xenium (ISS-based) 128 platforms, will allow for imaging-based co-profiling of a few to…”