Environmental standardization: cure or cause of poor reproducibility in animal experiments?

By S. H. Richter, Joseph P. Garner, H. Würbel. Nature Methods, 2009

390 citations recorded by the source corpus.

Subfields: Ecology, Small Animals

View Paper: https://www.semanticscholar.org/paper/50b8c8e129dcdee4cdb894b961fcc0392f441abc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Small Animals

1. G. Davies

Citations in the corpus

• Caring for the Multiple and the Multitude: Assembling Animal Welfare and Enabling Ethical Critique (2012, background): “The desire to minimise variability within experimental settings risks generating experimental artefacts, which are both idiosyncratic to that situation and, given standardisation, highly reproducible, but lacking in applicability to other places, populations and species (Richter et al, 2009; 2010).”
• Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options (2020, background): “Moreover, the high level of standardization in animal facilities and in the design of preclinical studies in laboratory animals can contribute to a poor reproducibility and limited translation of preclinical findings to clinical application (Richter et al., 2009).”
• Neuroendocrinology of coping styles: towards understanding the biology of individual variation. (2010, neutral): “cult to reproduce in different laboratories [102,149].”