Global existence and boundedness in a parabolic-elliptic Keller-Segel system with general sensitivity

By Kentarou Fujie, T. Senba. 2015

85 citations recorded by the source corpus.

This paper is concerned with the parabolic-elliptic Keller-Segel system with signal-dependent sensitivity $\chi(v)$, \begin{align*} \begin{cases} u_t=\Delta u - \nabla \cdot ( u \nabla \chi(v)) &\mathrm{in}\ \Omega\times(0,\infty), \\ 0=\Delta v -v+u &\mathrm{in}\ \Omega\times(0,\infty), \end{cases} \end{align*} under homogeneous Neumann boundary condition in a smoothly bounded domain $\Omega \subset \mathbb{R}^2$ with nonnegative initial data $u_0 \in C^{0}(\overline{\Omega})$, $\not\equiv 0$.   In the special case $\chi(v)=\chi_0 \log v\, (\chi_0>0)$, global existence and boundedness of the solution to the system were proved under some smallness condition on $\chi_0$ by Biler (1999) and Fujie, Winkler and Yokota (2015). In the present work, global existence and boundedness in the system will be established for general sensitivity $\chi$ satisfying $\chi'>0$ and $\chi'(s) \to 0 $ as $s\to \infty$. In particular, this establishes global existence and boundedness in the case $\chi(v)=\chi_0\log v$ with large $\chi_0>0$. Moreover, although the methods in the previous results are effective for only few specific cases, the present method can be applied to more general cases requiring only the essential conditions. Actually, our condition is necessary, since there are many radial blow-up solutions in the case $\inf_{s>0} \chi^\prime (s) >0$.

Subfields: Cancer Research, Modeling and Simulation, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/50a300f3112e64dfe7e2281e11ed0fdf22818077

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In Cancer Research

  1. Johannes Lankeit
  2. Michael Winkler
  3. Youshan Tao
  4. Tobias Black

In Modeling and Simulation

  1. Johannes Lankeit
  2. Michael Winkler
  3. Youshan Tao
  4. Tian Xiang
  5. Mario Fuest
  6. Yulan Wang
  7. Zhaoyin Xiang
  8. Giuseppe Viglialoro

In Molecular Biology

  1. Johannes Lankeit
  2. Michael Winkler
  3. Youshan Tao
  4. Tian Xiang
  5. Giuseppe Viglialoro
  6. Mario Fuest
  7. Chunhua Jin
  8. Yulan Wang

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