The Dendritic Cell-Specific Adhesion Receptor DC-SIGN Internalizes Antigen for Presentation to T Cells1

By A. Engering, Teunis B. Geijtenbeek, S. V. van Vliet, Mietske Wijers, E. van Liempt, N. Demaurex, A. Lanzavecchia, J. Fransen, C. Figdor, V. Piguet and 1 more. Journal of Immunology, 2002

696 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/508e8c301ded40e8b3c296373f2ce6733057aff8

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Citations in the corpus

The CD8+ Dendritic Cell Subset Selectively Endocytoses Dying Cells in Culture and In Vivo (2002, background): “The primers were: for integrin v (5 - CAA GCT CAC TCC CAT CAC-3 , 5 -GGG TGT CTT GAT TCT CAA AGG G-3 ), integrin 3 (5 -TTG CTA CTC TGC TCA TCT GGA AGC-3 , 5 -TCC CCA CAC TCG TCA CAC ACA TAAG-3 ), integrin 5A (5 -TTG CCA AGT TCC AAA GTG A-3 , 5 -GCG TGA CCT TTT TAT TTC AT-3 ), integrin 5B (5 -TGC CAA”
Characterization of β-Glucan Recognition Site on C-Type Lectin, Dectin 1 (2004, background): “The cytoplasmic domain of dectin 1 also has three consecutive acidic amino acid residues that are a putative internalizing signal sequence for the lysosomal endosome (5, 17), and it also has a putative immunoreceptor tyrosine-based activating motif (ITAM)-like region consisting of a YXXL amino acid ”
Mycobacteria Target DC-SIGN to Suppress Dendritic Cell Function (2003, methodology): “Recently, we demonstrated that binding of soluble ligands or antibodies to DC-SIGN triggers internalization of the DC-SIGN–ligand complex to late endosomes/lysosomes, and results in down-regulation of DC-SIGN from the surface (15).”
Efficient Targeting of Protein Antigen to the Dendritic Cell Receptor DEC-205 in the Steady State Leads to Antigen Presentation on Major Histocompatibility Complex Class I Products and Peripheral CD8+ T Cell Tolerance (2002, background): “Other receptors are more DC restricted, e.g., Langerin or CD207 (25), DC-SIGN or CD209 (26, 27), an asialoglycoprotein receptor (28), and BDCA-2 (29), but at this time, these receptors have not been shown to mediate the selective presentation of antigens on the MHC class I and II products of DCs in ”
Vaccine adjuvants: mechanisms and platforms (2023, background): “Immunostimulants with a carbohydrate structure generally activate CLRs, which subsequently induce APCs to initiate the internalization, processing and presentation of antigens to enhance the development of adaptive immune responses.(41,42) In addition, some immunostimulants can activate CLRs, which ”