Recent Advances in Bacteriophage Based Biosensors for Food-Borne Pathogen Detection
By Amit Singh, Somayyeh Poshtiban, S. Evoy. Italian National Conference on Sensors, 2013
330 citations recorded by the source corpus.
Foodborne diseases are a major health concern that can have severe impact on society and can add tremendous financial burden to our health care systems. Rapid early detection of food contamination is therefore relevant for the containment of food-borne pathogens. Conventional pathogen detection methods, such as microbiological and biochemical identification are time-consuming and laborious, while immunological or nucleic acid-based techniques require extensive sample preparation and are not amenable to miniaturization for on-site detection. Biosensors have shown tremendous promise to overcome these limitations and are being aggressively studied to provide rapid, reliable and sensitive detection platforms for such applications. Novel biological recognition elements are studied to improve the selectivity and facilitate integration on the transduction platform for sensitive detection. Bacteriophages are one such unique biological entity that show excellent host selectivity and have been actively used as recognition probes for pathogen detection. This review summarizes the extensive literature search on the application of bacteriophages (and recently their receptor binding proteins) as probes for sensitive and selective detection of foodborne pathogens, and critically outlines their advantages and disadvantages over other recognition elements.
Subfields: Ecology, Molecular Biology, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/50514cd1c46c6796020e5753256c3899a78157d8
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Citations in the corpus
- Rapid methods for the detection of foodborne bacterial pathogens: principles, applications, advantages and limitations (2015, background): “Biosensors are easy to operate and they do not require sample pre-enrichment, unlike nucleic-acid based methods and immunological methods which require sample pre-enrichment for concentrating the pathogens before detection (Singh et al., 2013).”
- Status of pathogens, antibiotic resistance genes and antibiotic residues in wastewater treatment systems (2017, methodology): “…(Omar and Barnard 2010) but emerging techniques that include the detection of bacteriophages (Deshmukh et al. 2016; Santiago-Rodriguez et al. 2016; Singh et al. 2013), Polymerase chain reaction (PCR)-based methods amplifying bacterial 16S or 23S rRNA genes, such as traditional PCR (Maheux et al.…”