The role of natural product chemistry in drug discovery.

By M. Butler. Journal of Natural Products, 2004

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Curcumin as "Curecumin": from kitchen to clinic. (2008, background): “[2] Butler MS.”
Discovery and resupply of pharmacologically active plant-derived natural products: A review (2015, background): “In contrast, pharmaceutical leads originating from synthetic libraries are usually comparably easy to generate and modify using simple chemical approaches (Butler, 2004; Henrich and Beutler, 2013; Li and Vederas, 2009).”
Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice (2020, background): “…including salicylic acid, the precursor of aspirin (Salix sp.), cocaine (Erythroxylum coca), quinine (Cinchona officinalis), digitoxin (Digitalis purpurea and Digitalis lanata), and many others with pharmaceutical and clinical potential (Newman et al., 2000; Butler, 2004; Ogbonna et al., 2012).”
Drug discovery from medicinal plants. (2005, background): “As such, many pharmaceutical companies have eliminated or scaled down their natural product research (Butler, 2004; Koehn and Carter, 2005).”