Bacteriophage host range and bacterial resistance.

By P. Hyman, S. Abedon. Advances in Applied Microbiology, 2010

749 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Phage cocktails and the future of phage therapy. (2013, background): “In particular, although many pathogens can be rapidly identified to the species level, bacteriophages are often not effective against all strains, even within a single bacterial species [5].”
Bacteria–phage coevolution as a driver of ecological and evolutionary processes in microbial communities (2014, background): “There are reasons to think that phage specificity (i.e. narrow host range), as opposed to generalism (broad host range), is the rule rather than the exception in nature (reviewed in Hyman & Abedon, 2010; Koskella & Meaden, 2013; Martiny et al., 2014).”
Overcoming the challenges of phage therapy for industrial aquaculture: A review (2019, methodology): “In Gill and Hyman’s review on the subject, they discussed that current methods used to search phages might favor the isolation of short-ranged phages (Gill and Hyman, 2010).”
Phage therapy in clinical practice: treatment of human infections. (2010, background): “The host receptors that they target often vary widely even within the same species, while multispecies bacterial infections are common (see also [9,10]).”
Molecular and Evolutionary Determinants of Bacteriophage Host Range. (2019, background): “Finally, it has been noted that some methods, like spot assays, may overestimate phage host range, meaning that evaluations of phage host range must be treated with some caution [79].”