Crystal Structure of a Neutralizing Human IgG Against HIV-1: A Template for Vaccine Design

By E. Saphire, P. Parren, R. Pantophlet, M. Zwick, Garrett M. Morris, P. Rudd, R. Dwek, R. Stanfield, D. Burton, Ian A. Wilson. Science, 2001

947 citations recorded by the source corpus.

Subfields: Immunology, Radiology, Nuclear Medicine and Imaging, Virology

View Paper: https://www.semanticscholar.org/paper/4f86648b15cda1e7be80d6c4c75a88f23f2ecd0e

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In Immunology

1. Michel C. Nussenzweig
2. Pamela J. Bjorkman

Citations in the corpus

• Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies (2020, positive): “, 2004) and with the hinge region indicated by a dotted line since it is disordered in crystal structures of intact IgGs (Harris et al., 1992; Harris et al., 1998; Saphire et al., 2001).”
• Broadly Neutralizing Antibodies Targeted to the Membrane-Proximal External Region of Human Immunodeficiency Virus Type 1 Glycoprotein gp41 (2001, background): “The IgG molecule dimensions are taken from those of a human IgG1 molecule (46).”