Injectable hydrogels for cartilage and bone tissue engineering

By Mei Liu, Xin-Peng Zeng, Chao Ma, Huan Yi, Zeeshan Ali, Xianbo Mou, Song Li, Yan Deng, N. He. Bone Research, 2017

1,041 citations recorded by the source corpus.

Tissue engineering has become a promising strategy for repairing damaged cartilage and bone tissue. Among the scaffolds for tissue-engineering applications, injectable hydrogels have demonstrated great potential for use as three-dimensional cell culture scaffolds in cartilage and bone tissue engineering, owing to their high water content, similarity to the natural extracellular matrix (ECM), porous framework for cell transplantation and proliferation, minimal invasive properties, and ability to match irregular defects. In this review, we describe the selection of appropriate biomaterials and fabrication methods to prepare novel injectable hydrogels for cartilage and bone tissue engineering. In addition, the biology of cartilage and the bony ECM is also summarized. Finally, future perspectives for injectable hydrogels in cartilage and bone tissue engineering are discussed.

Subfields: Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/4f685a8689e6fa1d590b55ac625cea79998643d6

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1. Jianxun Ding
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4. Xue-zhou Li
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Citations in the corpus

• Mesenchymal Stem Cells for Regenerative Medicine (2019, background): “Injectable hydrogels enable minimally invasive treatment of large areas of cartilage defects [75]; thus, hydrogels loaded with MSCs and stimulating factors are highly efficacious for the repair of cartilage damage.”