IL-25-responsive, lineage-negative KLRG1hi cells are multipotential “inflammatory” type 2 innate lymphoid cells

By Yuefeng Huang, Liying Guo, J. Qiu, X. Chen, J. Hu‐Li, U. Siebenlist, P. Williamson, J. Urban, W. E. Paul. Nature Immunology, 2014

597 citations recorded by the source corpus.

Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to the expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing ability and provided partial protection against Candida albicans. We propose that iILC2 cells are transient progenitors of ILCs mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi.

Subfields: Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/4f5fb9c2d1203d3e472da2a3df361b13a3fe0cfb

Citations in the corpus

• Innate Lymphoid Cells: 10 Years On. (2018, unknown): “IL-25-responding ILC2s arise from resting intestinal ILC2s in response to infection with helminths (Huang et al., 2015; Neill et al., 2010).”