Role of oxidative stress in cardiac hypertrophy and remodeling.

By E. Takimoto, D. Kass. HYPERTENSION, 2007

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Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets (2015, background): “Studies have demonstrated that hypertrophic stimuli such as angiotensin II (Ang II), ET-1, catecholamines, cytokines and biomechanical stretch can induce increased ROS production in cardiomyocytes (Laskowski et al. 2006; Liu et al. 2004), and this can activate a range of hypertrophic signaling media”
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances (2025, positive): “334 Recently, Seok et al. demonstrated that oxidative modi ﬁ cation by ROS formed 8-oxoguanine in miRNAs seed regions, which led to adenine mispairing mutation with mRNA, and promoted cardiac hypertrophy.”