FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations
By G. Santos, A. Schroeder, J. Goodman, V. Strelets, Madeline A. Crosby, Jim Thurmond, D. Emmert, W. Gelbart. Nucleic Acids Res., 2014
439 citations recorded by the source corpus.
Release 6, the latest reference genome assembly of the fruit fly Drosophila melanogaster, was released by the Berkeley Drosophila Genome Project in 2014; it replaces their previous Release 5 genome assembly, which had been the reference genome assembly for over 7 years. With the enormous amount of information now attached to the D. melanogaster genome in public repositories and individual laboratories, the replacement of the previous assembly by the new one is a major event requiring careful migration of annotations and genome-anchored data to the new, improved assembly. In this report, we describe the attributes of the new Release 6 reference genome assembly, the migration of FlyBase genome annotations to this new assembly, how genome features on this new assembly can be viewed in FlyBase (http://flybase.org) and how users can convert coordinates for their own data to the corresponding Release 6 coordinates.
Subfields: Insect Science, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/4eaa27b0f1420455205ca466f7868c694bcb8059
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In Molecular Biology
Citations in the corpus
- FlyBase at 25: looking to the future (2016, background): “Recent years have seen the completion of Release 6 of the Drosophila melanogaster reference genome (4,5); a complete reannotation of the reference genome on the basis of RNA-Seq coverage data, RNA-Seq junction data, and transcription start site profiles from the modENCODE project (6–10); and the gen”