The 2019 WHO classification of tumours of the digestive system

By I. Nagtegaal, R. Odze, D. Klimstra, V. Paradis, M. Rugge, P. Schirmacher, K. Washington, F. Carneiro, Ian A. Cree. Histopathology, 2019

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The WHO Classification of Digestive System Tumours presented in the first volume of the WHO Classification of Tumours series' fifth edition reflects important advancements in our understanding of tumours of the digestive system (table 1). For the first time, certain tumour types are defined as much by their molecular phenotype as their histological characteristics; however, histopathological classification remains the gold standard for diagnosis in most instances. The WHO Classification of Tumours series is designed to be used worldwide, including those settings where a lack of tissue samples or of specific technical facilities limits the pathologist's ability to rely on molecular testing. This article is protected by copyright. All rights reserved.

Subfields: Cancer Research, Oncology, Surgery

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• The 2021 WHO Classification of Lung Tumors: Impact of advances since 2015. (2021, background): “Because of these controversial data, diagnostic criteria of pulmonary (and thymic) NENs remain different from those of their digestive and pancreatic NEN counterparts, where Ki-67 index is an integral part of the diagnostic parameters for stratifying NETs and carcinomas in three grades.(148) Neverth”