Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances
By Joseph J. Volpe. Lancet Neurology, 2009
2,316 citations recorded by the source corpus.
Brain injury in premature infants is of enormous public health importance because of the large number of such infants who survive with serious neurodevelopmental disability, including major cognitive deficits and motor disability. This type of brain injury is generally thought to consist primarily of periventricular leukomalacia (PVL), a distinctive form of cerebral white matter injury. Important new work shows that PVL is frequently accompanied by neuronal/axonal disease, affecting the cerebral white matter, thalamus, basal ganglia, cerebral cortex, brain stem, and cerebellum. This constellation of PVL and neuronal/axonal disease is sufficiently distinctive to be termed “encephalopathy of prematurity”. The thesis of this Review is that the encephalopathy of prematurity is a complex amalgam of primary destructive disease and secondary maturational and trophic disturbances. This Review integrates the fascinating confluence of new insights into both brain injury and brain development during the human premature period.
Subfields: Pediatrics, Perinatology and Child Health, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/4e78b37b2f625f91b15d00639e15ecbec1a27f0c
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Pediatrics, Perinatology and Child Health
In Pulmonary and Respiratory Medicine
Citations in the corpus
- Robust Super-resolution Volume Reconstruction from Slice Acquisitions: Application to Fetal Brain MRI (2010, background): “The reconstruction of volumetric fetal brain MRI from slice acquisitions may improve the efficacy of clinical evaluation but also greatly enhances the capacity of image analysis and research on the dynamics of brain maturation [4], brain development [7], [8], and the mechanism of brain injury [9].”
- Characterization of aperiodic and theta activity in preterm infants using EEG: Insights into cerebral maturation and inter-individual variability (2026, unknown): “Given diffuse white matter alterations commonly reported in preterm born infants (Kline et al., 2021; Volpe, 2009), it is possible that prematurity disrupts how distributed regions coordinate their rhythmic activity (ie. inter-regional synchronization patterns), even when each region individually…”