TFOS DEWS II Tear Film Report
By M. Willcox, P. Argüeso, G. Georgiev, J. Holopainen, G. Laurie, T. Millar, E. Papas, Jannick P. Rolland, T. Schmidt, U. Stahl and 4 more. The ocular surface, 2017
908 citations recorded by the source corpus.
The members of the Tear Film Subcommittee reviewed the role of the tear film in dry eye disease (DED). The Subcommittee reviewed biophysical and biochemical aspects of tears and how these change in DED. Clinically, DED is characterized by loss of tear volume, more rapid breakup of the tear film and increased evaporation of tears from the ocular surface. The tear film is composed of many substances including lipids, proteins, mucins and electrolytes. All of these contribute to the integrity of the tear film but exactly how they interact is still an area of active research. Tear film osmolarity increases in DED. Changes to other components such as proteins and mucins can be used as biomarkers for DED. The Subcommittee recommended areas for future research to advance our understanding of the tear film and how this changes with DED. The final report was written after review by all Subcommittee members and the entire TFOS DEWS II membership.
Subfields: Immunology and Allergy, Public Health, Environmental and Occupational Health, Radiology, Nuclear Medicine and Imaging
View Paper: https://www.semanticscholar.org/paper/4e32bc8ec7e6cfaad0d885355c706480039a0782
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- J. Craig
- J. Wolffsohn
- Kelly K. Nichols
- M. Willcox
- F. Stapleton
- E. Akpek
- A. Bron
- Lyndon Jones
Citations in the corpus
- TFOS DEWS II Definition and Classification Report. (2017, methodology): “A number of critical points were discussed, including acknowledgement that a loss of tear film homeostasis can arise from a multitude of factors that encompass eyelid and blink abnormalities, in addition to ocular surface or tear component deficiencies [1,5].”
- TFOS DEWS II Report Executive Summary. (2017, background): “A number of drugs in systemic use, such as antihistamines, b-blockers, antispasmodics, diuretics and some psychotropic drugs, can cause a reduction in lacrimal secretion and are risk factors for DED [3,8].”