Isoprenoid biosynthesis: the evolution of two ancient and distinct pathways across genomes.

By B. Lange, T. Rujan, William F. Martin, R. Croteau. Proceedings of the National Academy of Sciences of the United States of America, 2000

867 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/4e1775b5100e81ae89eab206660c38184d5378f5

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Citations in the corpus

Isoprene Production Via the Mevalonic Acid Pathway in Escherichia coli (Bacteria) (2012, background): “The methylerythritol phosphate (MEP) pathway is of prokaryotic bacterial origin and present in most bacteria, cyanobacteria, and plant plastids [22–26].”
Network analysis of the MVA and MEP pathways for isoprenoid synthesis. (2013, background): “, DXS from αproteobacteria, MCT and CMK from chlamydias, and MDS from Aquifex) (72).”
Hydrogen isotope fractionation in lipids of the methane-oxidizing bacterium Methylococcus capsulatus (2002, methodology): “In general, bacteria use only one isoprenoid pathway, not both (Lange et al., 2000).”
Sterols and other triterpenoids: source specificity and evolution of biosynthetic pathways (2005, background): “It was proposed by Lewin (1981) that prochlorophytes represent existing forms of an ancestor of green chloroplasts, although this view was soon contested.”
A unified mechanism of action for volatile isoprenoids in plant abiotic stress. (2009, background): “In plants, two separate metabolic pathways are responsible for the production of the C 5 building block of isoprenoids: the cytosolic mevalonic acid (MVA) pathway, and the plastidic 2- C -methyl- D -erythritol 4-phosphate (MEP) pathwa”
Secondary Metabolites as Plant Traits: Current Assessment and Future Perspectives (2002, background): “Two distinct pathways to IPP have been discovered so far: (1) the mevalonate pathway, and, recently, (2) the 1-deoxylulose-5-phosphate (DXP) pathway (Rohmer, 1999; Lichtenthaler, 1999; Lange et al., 2000; Eisenreich et al., 2001).”
On the origins of cells: a hypothesis for the evolutionary transitions from abiotic geochemistry to chemoautotrophic prokaryotes, and from prokaryotes to nucleated cells. (2003, methodology): “Such differences would include their use of many fundamentally different cofactors such as pterin derivatives versus tetrahydrofolate, coenzyme B, methanofuran, coenzyme F420, coenzyme M and cobamids in many archaebacteria (see DiMarco et al. 1990; Thauer 1998; White 2001), their use of different pa”
Process Design and Economics for the Conversion of Lignocellulosic Biomass to Hydrocarbons: Dilute-Acid and Enzymatic Deconstruction of Biomass to Sugars and Biological Conversion of Sugars to Hydrocarbons (2013, background): “There are two metabolic pathways leading to the production of the precursor farnesene; the mevalonic acid (MVA) pathway and the more recently characterized deoxyxylulose-5-phosphate (DXP) pathway, which is also known as the methylerythritol phosphate (MEP) pathway [116].”
Molecular Paleohydrology: Interpreting the Hydrogen-Isotopic Composition of Lipid Biomarkers from Photosynthesizing Organisms (2012, background): “In contrast, cyanobacteria possess no MVA pathway; thus, they synthesize both hopanoids and isoprenoids via the DOXP/MEP pathway (Lange et al. 2000).”