Wnt signals are transmitted through N‐terminally dephosphorylated β‐catenin

By F. Staal, M. van Noort, G. Strous, Hans Clevers. 2002

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Nucleo-cytoplasmic distribution of β-catenin is regulated by retention (2006, background): “Wnt signalling does not affect -catenin nucleocytoplasmic shuttling Activation of the Wnt pathway was suggested to shift -catenin to the nucleus (Staal et al., 2002).”
The ins and outs of APC and β‐catenin nuclear transport (2002, background): “…also be increased experimentally by overexpressing stable β-catenin in transgenic mice (Harada et al., 1999) or in cell lines (Morin, 1999) or by drug-mediated blockage of β-catenin degradation (Simcha et al., 1998; Henderson et al., 2002), although this is not always the case (Staal et al., 2002).”
Purified Wnt5a Protein Activates or Inhibits β-Catenin–TCF Signaling Depending on Receptor Context (2006, background): “Furthermore, previous reports have suggested that the accumulation of b-catenin and Wnt signal transduction are separable events by showing that b-catenin protein levels alone do not dictate signal output but rather the phosphorylation state of b-catenin [49,50].”