Nitrogen-Doped Carbon Nanomaterials as Highly Active and Specific Peroxidase Mimics

By Yihui Hu, Xuejiao J. Gao, Yunyao Zhu, Faheem Muhammad, Shihua Tan, Wen Cao, Shichao Lin, Zhongchao Jin, Xingfa Gao, Hui Wei. Chemistry of Materials, 2018

257 citations recorded by the source corpus.

Nanozymes, the enzyme-mimicking nanomaterials, have been developed to overcome the low stability and high cost of natural enzymes. Unlike highly active and specific enzymes, however, the catalytic activities of nanozymes are moderate and lack specificity. To address these issues, herein we demonstrated an effective and general strategy to specifically enhance the peroxidase-mimicking activities of carbon nanozymes. By doping heteroatom nitrogen (N) into reduced graphene oxide (rGO) and mesoporous carbon (MC), their peroxidase-mimicking activities were enhanced by over 100- and 60-fold, respectively. Moreover, N-doping did not significantly affect the oxidase-, superoxide dismutase (SOD)-, or catalase-mimicking activities of rGO and MC, demonstrating a specific enhancement of the peroxidase-mimicking activities. To understand the origin of the specific enhancement, we performed density functional theory calculations to examine the catalytic reaction mechanisms responsible for the peroxidase-, catalase-, ox...

Subfields: Electrical and Electronic Engineering, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/4dceb0146f7be18ae1cd1795eae39e501fffb63e

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In Electrical and Electronic Engineering

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Citations in the corpus

• Coordination Number Regulation of Molybdenum Single-Atom Nanozyme Peroxidase-like Specificity (2020, methodology): “Density functional theory (DFT) calculations are used to identify the most promising candidate-specific peroxidase mimics in a series of Mo–Nx–C single-atom models.(31,32) The work is guided by the idea that coordination number may be the key controlling parameter, and therefore, particular emphasis”