The Complete Gene Sequence of Titin, Expression of an Unusual ≈700-kDa Titin Isoform, and Its Interaction With Obscurin Identify a Novel Z-Line to I-Band Linking System

By M. Bang, T. Centner, F. Fornoff, A. J. Geach, M. Gotthardt, M. Mcnabb, C. Witt, D. Labeit, C. Gregorio, H. Granzier and 1 more. 2001

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Mutations of TTN, encoding the giant muscle filament titin, cause familial dilated cardiomyopathy (2002, methodology): “We screened 313 of the 363 TTN exons expressed in cardiac tissu”
Striated muscle cytoarchitecture: an intricate web of form and function. (2002, background): “It is restricted to striated muscle and has 57 Ig/FN3 domains as well as signaling domains (Bang et al. 2001a).”
Discovery Through the Computational Microscope (2009, neutral): “…titin is composed of 300 modular domains, 90% of which share immunoglobulin (Ig) or fibronectin type 3 (FN3) folds (Labeit and Kolmerer, 1995; Bang et al., 2001) with the remaining domains being composed of flexible insertion sequences such as proximal N2B and distal PEVK regions (rich in…”
Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction. (2007, background): “N2BA–titin-isoforms contain in addition, a “middle-Ig-domain” region (I28–I79), an “N2A”-domain, and a PEVK-segment of variable length [ 12 ].”