Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

By Beverly L. Davidson, C. Stein, Jason A. Heth, Inês H Martins, R. Kotin, T. Derksen, J. Zabner, A. Ghodsi, J. Chiorini. Proceedings of the National Academy of Sciences of the United States of America, 2000

642 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/4d79fdc369093b6187f9915b819787fc2d399712

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In Genetics

1. R. J. Reece
2. B. Davidson

In Molecular Biology

1. P. McCray
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Citations in the corpus

• Prevalence of Serum IgG and Neutralizing Factors Against Adeno-Associated Virus (AAV) Types 1, 2, 5, 6, 8, and 9 in the Healthy Population: Implications for Gene Therapy Using AAV Vectors (2010, neutral): “1 for AAV2 (Li et al. , 1997), pLT-RC02 for AAV1 (Riviere et al. , 2006), pLT-RC03 for AAV5 (Riviere et al. , 2006), pLTRCO6 for AAV6 (Riviere et al. , 2006), p5e18-VD2-8 for AAV8 (Gao et al. , 2002), and pAAV-2 = 9 for AAV9 (Gao et al. , 2004); and the relevant pAAV2 vector plasmid.”
• Analysis of Genes and Genomes (2004, positive): “AAV vectors have been used to introduce foreign DNA into a wide variety of cell types, including neurons (Davidson et al., 2000), muscle (Pruchnic et al.”
• Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system. (2004, positive): “rAAV5 has been shown to have higher transduction efficiency and higher levels of transgene expression than rAAV2 in ST and cerebellum [32,48].”
• Adeno-associated virus serotypes: vector toolkit for human gene therapy. (2006, neutral): “While AAV2 shows widespread transduction throughout the entire midbrain, AAV4 appears to transduce specific cell types [66], such as the ependyma and astrocytes in the subventricular zone.”
• Current prospects for RNA interference-based therapies (2011, positive): “Alternatively, researchers have taken advantage of the natural tropism 90, 91 or modified tropism of viral vectors for cell and tissue targeting 82 , or have used cell-specific promoters to express the silencing RNAs.”