Virus-like particles: Passport to immune recognition
By E. Grgacic, David A Anderson. Methods, 2006
605 citations recorded by the source corpus.
Virus-like particles (VLPs) are formed by the self-assembly of envelope and/or capsid proteins from many viruses. In many cases such VLPs have structural characteristics and antigenicity similar to the parental virus, and some have already proven successful as vaccines against the cognate virus infection. The structural components of some VLPs have also proven amenable to the insertion or fusion of foreign antigenic sequences, allowing the production of chimeric VLPs exposing the foreign antigen on their surface. Other VLPs have been used as carriers for foreign antigens, including non-protein antigens, via chemical conjugation. This review outlines some of the advantages, disadvantages, and technical considerations for the use of a wide range of VLP systems in vaccine development.
Subfields: Biotechnology, Ecology, Infectious Diseases
View Paper: https://www.semanticscholar.org/paper/4d0d00a02157f161f0b4ce42f2914107c421ba47
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Biotechnology
In Ecology
In Infectious Diseases
Citations in the corpus
- Bio-inspired, bioengineered and biomimetic drug delivery carriers (2011, background): “Although VLPs have a homogenous size and morpholog”
- Self-assembling protein nanoparticles in the design of vaccines (2015, positive): “This bipartite approach of separately producing and purifying the optimized antigen and carrier components, followed by their conjugation, avoids the potential size limitation of antigens that can be incorporated into a nano-particle via genetic fusion [70].”