A neurocentric perspective on glioma invasion

By V. Cuddapah, S. Robel, Stacey Watkins, H. Sontheimer. Nature Reviews Neuroscience, 2014

756 citations recorded by the source corpus.

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to escape complete surgical resection and chemo- and radiation therapy. Gliomas use the same tortuous extracellular routes of migration that are travelled by immature neurons and stem cells, frequently using blood vessels as guides. They repurpose ion channels to dynamically adjust their cell volume to accommodate to narrow spaces and breach the blood–brain barrier through disruption of astrocytic endfeet, which envelop blood vessels. The unique biology of glioma invasion provides hitherto unexplored brain-specific therapeutic targets for this devastating disease.

Subfields: Cellular and Molecular Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/4c6a84c67b0c2f99fd7d53c7510ebf3a4fba553e

Citations in the corpus

• Brain tumour cells interconnect to a functional and resistant network (2015, neutral): “Oligodendroglioma cell lines containing t(1;19)(q10;p10).”
• Neuronal Activity Promotes Glioma Growth through Neuroligin-3 Secretion (2015, neutral): “A wealth of elegant data illustrates that neurotransmitters and neuropeptides can affect glioma cell behavior (Cuddapah et al., 2014; Labrakakis et al., 1998; Seifert and Sontheimer, 2014; Synowitz et al., 2001); for example, glutamate secreted from glioma cells influences their own proliferation an”