Elevated β-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

By Libang Yang, Kristina Lindholm, R. Yan, Martin Citron, W. Xia, Xiao‐Li Yang, T. Beach, L. Sue, Philip C. Wong, Donald L. Price and 2 more. Nature Medicine, 2003

758 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Physiology

View Paper: https://www.semanticscholar.org/paper/4c0858469d4d7f172082d24041784375c9c77b0b

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In Physiology

Citations in the corpus

APP processing in Alzheimer's disease (2011, background): “studies have found that BACE1 protein and activity levels are elevated in the regions of the brain affected by AD [82,83].”
An Overview of APP Processing Enzymes and Products (2010, neutral): “Also, BACE1 expression and activity is increased in brains of AD patients (Holsinger et al. 2002;Yang et al. 2003).”
Amyloid Precursor Protein Processing and Alzheimer’s Disease (2011, background): “Excessive age-associated acetylation of the α-secretase gene may diminish nonamyloidogenic processing of APP (Donmez et al. 2010), whereas an increase in BACE1 activity, reported in early AD brain tissue, would increase amyloidogenic processing (Holsinger et al. 2002, Yang et al. 2003).”
Alzheimer’s Disease and the β-Amyloid Peptide (2010, neutral): “Although these studies indicate that BACE1 is the major β -secretase activity in brain, some residual activity might be attributable to BACE2 [38], and both forms of BACE can compete for substrate [39–43]. β -Secretase activity and protein are both signiﬁcantly increased in sporadic AD [44,46,46].”