A Cell-based Model of Hemostasis

By M. Hoffman, D. Monroe. Thrombosis and Haemostasis, 2001

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The European guideline on management of major bleeding and coagulopathy following trauma: fifth edition (2019, background): “rFVIIa acts on the endogenous coagulation system, but depends on adequate numbers of platelets and fibrinogen to support effective activity [704, 705].”
Molecular Intercommunication between the Complement and Coagulation Systems (2010, background): “As a result, a cell-based model of coagulation has been developed (55), which appears to much better mimic the complex interactions of cellular and plasma components in vivo.”
Management of bleeding following major trauma: an updated European guideline (2010, neutral): “through direct binding to activated platelets [308, 309].”
The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition (2016, background): “16 rFVIIa acts on the patient's own coagulation system and adequate numbers of platelets and 17 fibrinogen levels are needed to support activity [632, 633].”