Hereditary and Familial Colon Cancer

By K. Jasperson, T. Tuohy, D. Neklason, R. Burt. Gastroenterology, 2010

1,240 citations recorded by the source corpus.

Between 2% to 5% of all colon cancers arise in the setting of well defined inherited syndromes, including Lynch syndrome, familial adenomatous polyposis, MUTYH-associated polyposis, and certain hamartomatous polyposis conditions. Each is associated with a high risk of colon cancer. In addition to the syndromes, up to one-third of colon cancers exhibit increased familial risk, likely related to inheritance. A number of less penetrant, but possibly more frequent susceptibility genes have been identified for this level of inheritance. Clarification of predisposing genes allows for accurate risk assessment and more precise screening approaches. This review examines the colon cancer syndromes, their genetics and management, and also the common familial colon cancers with current genetic advances and screening guidelines.

Subfields: Oncology, Pathology and Forensic Medicine

View Paper: https://www.semanticscholar.org/paper/4beef0d632d520da2850b96b2decfb967d7f3b82

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Citations in the corpus

• Global colorectal cancer burden in 2020 and projections to 2040 (2021, background): “sporadic CRC is largely attributed to acquired somatic genetic mutations or epigenetic alterations induced by modifiable risk factors [67].”