Qualimap 2: advanced multi-sample quality control for high-throughput sequencing data
By Konstantin Okonechnikov, Ana Conesa, Fernando García-Alcalde. Bioinform., 2015
1,851 citations recorded by the source corpus.
Motivation: Detection of random errors and systematic biases is a crucial step of a robust pipeline for processing high-throughput sequencing (HTS) data. Bioinformatics software tools capable of performing this task are available, either for general analysis of HTS data or targeted to a specific sequencing technology. However, most of the existing QC instruments only allow processing of one sample at a time. Results: Qualimap 2 represents a next step in the QC analysis of HTS data. Along with comprehensive single-sample analysis of alignment data, it includes new modes that allow simultaneous processing and comparison of multiple samples. As with the first version, the new features are available via both graphical and command line interface. Additionally, it includes a large number of improvements proposed by the user community. Availability and implementation: The implementation of the software along with documentation is freely available at http://www.qualimap.org. Contact: meyer@mpiib-berlin.mpg.de Supplementary information: Supplementary data are available at Bioinformatics online.
Subfields: Clinical Biochemistry, Molecular Biology, Spectroscopy
View Paper: https://www.semanticscholar.org/paper/4b3b74aec92b46812ea87011058326794f59db10
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In Clinical Biochemistry
In Molecular Biology
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- Christian Kniep
- Günter Jäger
- Daniel C. Koboldt
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In Spectroscopy
Citations in the corpus
- EAGER: efficient ancient genome reconstruction (2016, methodology): “Finally, the method QualiMap [28], which reviews the overall mapping results, has been made accessible in the pipeline.”
- Best practices for variant calling in clinical sequencing (2020, methodology): “Sequencing metrics BEDTools [32], Picard tools [28], QualiMap 2 [33]”