General Anesthesia, Sleep, and Coma

By Emery N. Brown, R. Lydic, Nicholas D. Schiff. New England Journal of Medicine, 2010

1,217 citations recorded by the source corpus.

This review discusses the clinical and neurophysiological features of general anesthesia and their relationships to sleep and coma, focusing on the neural mechanisms of unconsciousness induced by selected intravenous anesthetic drugs.

Subfields: Anesthesiology and Pain Medicine, Cognitive Neuroscience, Developmental Neuroscience

View Paper: https://www.semanticscholar.org/paper/4b38f134e3df85014d0fc903c3124eca8c335ee6

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In Anesthesiology and Pain Medicine

In Cognitive Neuroscience

In Developmental Neuroscience

Adam E. Gaweda

Citations in the corpus

The spectral exponent of the resting EEG indexes the presence of consciousness during unresponsiveness induced by propofol, xenon, and ketamine (2019, neutral): “This is consistent with a slowing of the EEG and a redistribution of spectral power towards 591 lower frequencies, typically observed in general anesthesia [10,48,85,108].”
Reinforcement learning for closed-loop propofol anesthesia: a study in human volunteers (2014, background): “Cerebral electrical activity is correlated with consciousness (Brown et al., 2010), and hypnosis (suppression of awareness) displays as change in cortical electrical activity.”
Electroencephalogram signatures of loss and recovery of consciousness from propofol (2013, background): “In the United States, nearly 60,000 people receive GA daily for surgery alone (1), suggesting that no physicians manipulate the state of the brain more often or more profoundly than anesthesiologists.”
Resting‐state networks show dynamic functional connectivity in awake humans and anesthetized macaques (2013, background): “[Color figure can be viewed in the online issue, which is available at wileyonlinelibrary.com.] r 2165 r thereby precluding such processes related to conscious thought, mind wandering, memory formation, or changes in arousal and attention [Brown et al., 2010; Veselis, 2001].”
Hemispherotomy leads to persistent sleep-like slow waves in the isolated cortex of awake humans (2025, unknown): “Assessing EEG activity patterns currently represent the primary tool to characterize physiological [80,115], pharmacological [116–119], and pathological [45–47, 66 , Although NREM sleep, general anesthesia, and the unresponsive wakefulness syndrome do not always imply complete unconsciousness—since…”